Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes

Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes

Liposomes (LPs) as commonly used mRNA delivery systems remain to be rationally designed and optimized to ameliorate the antigen expression of mRNA vaccine in dendritic cells (DCs). In this study, we synthesized mannose-cholesterol conjugates (MPn-CHs) by click reaction using different PEG units (PEG...

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Bibliographic Details
Main Authors: Fazhan Wang, Wen Xiao, Mostafa A. Elbahnasawy, Xingting Bao, Qian Zheng, Linhui Gong, Yang Zhou, Shuping Yang, Aiping Fang, Mohamed M. S. Farag, Jinhui Wu, Xiangrong Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
mRNA vaccine
dendritic cell targeting liposomes
mannose conjugates
linker length
click reaction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00980/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00980/full

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