Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Pediatric acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy and is characterized by clonal heterogeneity. Genomic mutations can increase proliferative potential of leukemic cells and cause treatment resistance. However, mechanisms driving mutagenesis and clonal diversificati...

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Bibliographic Details
Main Authors: Željko Antić, Stefan H. Lelieveld, Cédric G. van der Ham, Edwin Sonneveld, Peter M. Hoogerbrugge, Roland P. Kuiper
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Genes
Subjects:
pediatric acute lymphoblastic leukemia
mutational signatures
clonal evolution
relapse development
APOBEC activity
thiopurine-associated DNA damage
Online Access:https://www.mdpi.com/2073-4425/12/2/214

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https://www.mdpi.com/2073-4425/12/2/214

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