Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock

Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock

Extracellular vesicles (EVs) are mRNA-containing cell fragments shed into circulation during pathophysiological events. DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B) regulate gene expression by modifying DNA methylation and altering transcription. Sepsis is a systemic insult resulting in vascul...

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Bibliographic Details
Main Authors: Duaa A. Dakhlallah, Jon Wisler, Marieta Gencheva, Candice M. Brown, Erin R. Leatherman, Kanhaiya Singh, Kathy Brundage, Todd Karsies, Ahmad Dakhlallah, Kenneth W. Witwer, Chandan K. Sen, Timothy D. Eubank, Clay B. Marsh
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Journal of Extracellular Vesicles
Subjects:
sepsis
dna methyltransferases (dnmt)
extracellular vesicles (evs)
diagnostic marker
epigenetics
septic shock
Online Access:http://dx.doi.org/10.1080/20013078.2019.1669881

Internet

http://dx.doi.org/10.1080/20013078.2019.1669881

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