Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

Wallerian degeneration of physically injured axons involves a well-defined molecular pathway linking loss of axonal survival factor NMNAT2 to activation of pro-degenerative protein SARM1. Manipulating the pathway through these proteins led to the identification of non-axotomy insults causing axon de...

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Bibliographic Details
Main Authors: Andrea Loreto, Ciaran S. Hill, Victoria L. Hewitt, Giuseppe Orsomando, Carlo Angeletti, Jonathan Gilley, Cristiano Lucci, Alvaro Sanchez-Martinez, Alexander J. Whitworth, Laura Conforti, Federico Dajas-Bailador, Michael P. Coleman
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Neurobiology of Disease
Subjects:
Axon degeneration
Mitochondrial dysfunction
NMNAT2
SARM1
Wallerian degeneration
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119303535

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http://www.sciencedirect.com/science/article/pii/S0969996119303535

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