Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24

Structure, Topology, and Dynamics of Membrane-Inserted Polypeptides and Lipids by Solid-State NMR Spectroscopy: Investigations of the Transmembrane Domains of the DQ Beta-1 Subunit of the MHC II Receptor and of the COP I Protein p24

MHC class II receptors carry important function in adaptive immunity and their malfunctioning is associated with diabetes type I, chronic inflammatory diseases and other autoimmune diseases. The protein assembles from the DQ alpha-1 and DQ beta-1 subunits where the transmembrane domains of these typ...

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Bibliographic Details
Main Authors: Evgeniy S. Salnikov, Christopher Aisenbrey, Bianca Pokrandt, Britta Brügger, Burkhard Bechinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
transmembrane dimer
highly specific protein-lipid interaction
sphingomyelin recognition motif
supported lipid bilayer
solid-state NMR
helix topology
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00083/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00083/full

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