An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor

The sequence of events that initiates T cell signaling is dictated by the specificities and order of activation of the tyrosine kinases that signal downstream of the T cell receptor. Using a platform that combines exhaustive point-mutagenesis of peptide substrates, bacterial surface-display, cell so...

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Bibliographic Details
Main Authors: Neel H Shah, Qi Wang, Qingrong Yan, Deepti Karandur, Theresa A Kadlecek, Ian R Fallahee, William P Russ, Rama Ranganathan, Arthur Weiss, John Kuriyan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-10-01
Series:eLife
Subjects:
tyrosine kinase
T cell receptor
ZAP-70
LAT
Lck
bacterial surface display
Online Access:https://elifesciences.org/articles/20105

Internet

https://elifesciences.org/articles/20105

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