Transcriptomic Response to 1,25-Dihydroxyvitamin D in Human Fibroblasts with or without a Functional Vitamin D Receptor (VDR): Novel Target Genes and Insights into VDR Basal Transcriptional Activity

Transcriptomic Response to 1,25-Dihydroxyvitamin D in Human Fibroblasts with or without a Functional Vitamin D Receptor (VDR): Novel Target Genes and Insights into VDR Basal Transcriptional Activity

The vitamin D receptor (VDR) mediates vitamin D actions beyond bone health. While VDR activation by 1,25-dihydroxyvitamin D (1,25D) leads to robust transcriptional regulation, less is known about VDR actions in the absence of 1,25D. We analyzed the transcriptomic response to 1,25D in fibroblasts bea...

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Bibliographic Details
Main Authors: Pedro L. F. Costa, Monica M. França, Maria L. Katayama, Eduardo T. Carneiro, Regina M. Martin, Maria A. K. Folgueira, Ana C. Latronico, Bruno Ferraz-de-Souza
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
vitamin D
calcitriol
microarray
gene expression
CYP24A1
cell proliferation
Online Access:https://www.mdpi.com/2073-4409/8/4/318

Internet

https://www.mdpi.com/2073-4409/8/4/318

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