Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain transgenic mice

Depletion of conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain transgenic mice

In this study, we introduced the bovine immunoglobulin μ heavy-chain gene (the orphaned gene on BTA11) into mouse germline cells. Bovine IgM was highly expressed in selected transgenic lines, and it largely inhibited rearrangements of the endogenous immunoglobulin heavy chain (IgH) genes in these li...

Full description

Bibliographic Details
Main Author: Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO
Format: Article
Language:English
Published: Higher Education Press 2014-06-01
Series:Frontiers of Agricultural Science and Engineering
Subjects:
bovine Ig μ heavy-chain|transgenic mice|B cell development|allelic exclusion|immune response|Ig repertoire
Online Access:http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-2-158.pdf

Internet

http://academic.hep.com.cn/fase/fileup/2095-7505/PDF/2095-7505-2014-2-158.pdf

Similar Items