Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II

Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II

Renal fibrogenesis is related to the development of diabetic nephropathy. TGF-β receptor II (TGF-β RII) plays a vital role during renal fibrogenesis by phosphorylation and activation of type I receptors and downstream regulators. Nicousamide is a 1.1 class of drug, which can inhibit renal fibrosis i...

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Bibliographic Details
Main Authors: Hai-jing Zhang, Jing Jin, Wan-qi Zhou, Yi Zhang, Yan Li, Jian-yi Liu, Sen Zhang, Xiao-guang Chen
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nicousamide
Renal fibrosis
Phosphorylation
TGF-β receptor II
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383511000621

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http://www.sciencedirect.com/science/article/pii/S2211383511000621

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