The new β amyloid-derived peptide Aβ1–6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity

The new β amyloid-derived peptide Aβ1–6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity

One attractive pharmacological strategy for Alzheimer's disease (AD) is to design small peptides to interact with amyloid-β (Aβ) protein reducing its aggregation and toxicity. Starting from clinical observations indicating that patients coding a mutated Aβ variant (AβA2V) in the heterozygous st...

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Bibliographic Details
Main Authors: Luisa Diomede, Margherita Romeo, Alfredo Cagnotto, Alessandro Rossi, Marten Beeg, Matteo Stravalaci, Fabrizio Tagliavini, Giuseppe Di Fede, Marco Gobbi, Mario Salmona
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Amyloid β
AβA2V
Oligomer
C. elegans
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300067

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http://www.sciencedirect.com/science/article/pii/S0969996116300067

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