Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats

Blockade of cholinergic transmission elicits somatic signs in nicotine-naïve adolescent rats

High doses of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine can elicit somatic signs resembling those associated with nicotine withdrawal in nicotine-naïve adult rats. Understanding this phenomenon, and its possible modulation by acute nicotine and age, could inform the use o...

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Bibliographic Details
Main Authors: Clare E. Schmidt, Katherine eManbeck, David eShelley, Andrew Charles Harris
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Adolescent
Mecamylamine
Nicotine
rat
Somatic signs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00239/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00239/full

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