Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity

Human cardiac stem cells inhibit lymphocyte proliferation through paracrine mechanisms that correlate with indoleamine 2,3-dioxygenase induction and activity

Abstract Transplantation of allogeneic human cardiac/stem progenitor cells (hCSCs) is currently being tested in several phase I/II clinical trials as a novel and promising therapy for restoration of myocardial tissue function in acute myocardial infarction (AMI) patients. Previous findings demonstra...

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Bibliographic Details
Main Authors: Maria J Sebastião, Ramón Menta, Margarida Serra, Itziar Palacios, Paula M Alves, Belén Sanchez, Olga DelaRosa, Wilfried Dalemans, Eleuterio Lombardo, Patrícia Gomes-Alves
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Stem Cell Research & Therapy
Subjects:
Cardiac stem/progenitor cells
Allogeneic stem cell therapy
Tryptophan metabolism
Immunosuppression
T lymphocytes
Online Access:http://link.springer.com/article/10.1186/s13287-018-1010-2

Internet

http://link.springer.com/article/10.1186/s13287-018-1010-2

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