Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels

Human Slack Potassium Channel Mutations Increase Positive Cooperativity between Individual Channels

Summary: Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack) Na+-activated K+ channel that give rise to three distinct forms of epilepsy. All produced...

Full description

Bibliographic Details
Main Authors: Grace E. Kim, Jack Kronengold, Giulia Barcia, Imran H. Quraishi, Hilary C. Martin, Edward Blair, Jenny C. Taylor, Olivier Dulac, Laurence Colleaux, Rima Nabbout, Leonard K. Kaczmarek
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009693

Internet

http://www.sciencedirect.com/science/article/pii/S2211124714009693

Similar Items