Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome

Fragile X syndrome (FXS) is an X chromosome-linked disease associated with severe intellectual disabilities. Previous studies using the Fmr1 knockout (KO) mouse, an FXS mouse model, have attributed behavioral deficits to synaptic dysfunctions. However, how functional deficits at neural network level...

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Bibliographic Details
Main Authors: Jie Li, Rena Y Jiang, Kristin L Arendt, Yu-Tien Hsu, Sophia R Zhai, Lu Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
fragile X syndrome
hippocampal engram
engram reactivation
enriched environment
Online Access:https://elifesciences.org/articles/61882

Internet

https://elifesciences.org/articles/61882

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