Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System

Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are incurable neurodegenerative conditions. A non-coding hexanucleotide (GGGGCC) repeat expansion in the c9orf72 gene is the most common genetic cause of ALS/FTD. We present a cellular model of c9ALS/FTD where induced neurons (iNe...

Full description

Bibliographic Details
Main Authors: Peter O. Bauer, Judith H. Dunmore, Hiroki Sasaguri, Vaclav Matoska
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis
c9ALS/FTD
c9orf72 expansion
induced neurons
iNeurons
RNA foci
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00935/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00935/full

Similar Items