A gene module identification algorithm and its applications to identify gene modules and key genes of hepatocellular carcinoma

Abstract To further improve the effect of gene modules identification, combining the Newman algorithm in community detection and K-means algorithm framework, a new method of gene module identification, GCNA-Kpca algorithm, was proposed. The core idea of the algorithm was to build a gene co-expressio...

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Bibliographic Details
Main Authors: Yan Zhang, Zhengkui Lin, Xiaofeng Lin, Xue Zhang, Qian Zhao, Yeqing Sun
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84837-y