Targeting multiple genes containing long mononucleotide A-T repeats in lung cancer stem cells

Targeting multiple genes containing long mononucleotide A-T repeats in lung cancer stem cells

Abstract Background Intratumour heterogeneous gene expression among cancer and cancer stem cells (CSCs) can cause failure of current targeted therapies because each drug aims to target the function of a single gene. Long mononucleotide A-T repeats are cis-regulatory transcriptional elements that con...

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Bibliographic Details
Main Authors: Narumol Bhummaphan, Piyapat Pin-on, Preeyaporn Plaimee Phiboonchaiyanan, Jirattha Siriluksana, Chatchawit Aporntewan, Pithi Chanvorachote, Apiwat Mutirangura
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Translational Medicine
Subjects:
Cancer stem cells
Lung cancer
Mononucleotide A-T repeats
Hallmark of cancer
Universal target
Online Access:https://doi.org/10.1186/s12967-021-02902-6

Internet

https://doi.org/10.1186/s12967-021-02902-6

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