Cardiac‐specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure

Cardiac‐specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure

Abstract Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can protect cardiac muscle cells from oxidative stress‐induced damage. Mammalian Grx3 has been shown to be critical in regulating cellular redox states. However, how Grx3 affects cardiac function by modul...

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Bibliographic Details
Main Authors: Jimmonique Donelson, Qiongling Wang, Tanner O. Monroe, Xiqian Jiang, Jianjie Zhou, Han Yu, Qianxing Mo, Qin Sun, Juan C. Marini, Xinquan Wang, Paul A. Nakata, Kendal D. Hirschi, Jin Wang, George G. Rodney, Xander H.T. Wehrens, Ninghui Cheng
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:Physiological Reports
Subjects:
Calcium handling
cardiac hypertrophy
glutaredoxin
heart failure
oxidative stress
Online Access:https://doi.org/10.14814/phy2.14071

Internet

https://doi.org/10.14814/phy2.14071

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