Limits on information transduction through amplitude and frequency regulation of transcription factor activity

Signaling pathways often transmit multiple signals through a single shared transcription factor (TF) and encode signal information by differentially regulating TF dynamics. However, signal information will be lost unless it can be reliably decoded by downstream genes. To understand the limits on dyn...

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Bibliographic Details
Main Authors: Anders S Hansen, Erin K O'Shea
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/06559