Neural-ODE for pharmacokinetics modeling and its advantage to alternative machine learning models in predicting new dosing regimens

Neural-ODE for pharmacokinetics modeling and its advantage to alternative machine learning models in predicting new dosing regimens

Summary: Forecasting pharmacokinetics (PK) for individual patients is a fundamental problem in clinical pharmacology. One key challenge is that PK models constructed using data from one dosing regimen must predict PK data for different dosing regimen(s). We propose a deep learning approach based on...

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Bibliographic Details
Main Authors: James Lu, Kaiwen Deng, Xinyuan Zhang, Gengbo Liu, Yuanfang Guan
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:iScience
Subjects:
Pharmacological parameters
Bioinformatics
Pharmacoinformatics
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221007720

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221007720

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