Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Reactive oxygen species–mediated switching expression of MMP-3 in stromal fibroblasts and cancer cells during prostate cancer progression

Abstract Studies on the aberrant control of extracellular matrices (ECMs) have mainly focused on the role of malignant cells but less on that of stromal fibroblasts during cancer development. Herein, by using paired normal and prostate cancer-associated stromal fibroblasts (CAFs) derived from a cocu...

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Bibliographic Details
Main Authors: Chia-Ling Hsieh, Che-Ming Liu, Hsin-An Chen, Shun-Tai Yang, Katsumi Shigemura, Koichi Kitagawa, Fukashi Yamamichi, Masato Fujisawa, Yun-Ru Liu, Wei-Hua Lee, Kuan-Chou Chen, Chia-Ning Shen, Cheng-Chieh Lin, Leland W. K. Chung, Shian-Ying Sung
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08835-9

Internet

https://doi.org/10.1038/s41598-017-08835-9

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