miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin

Abstract The B-lymphoma Moloney murine leukemia virus insertion region-1 protein (BMI1) acts as an oncogene in various cancers, including breast cancer. Recent evidence suggests that BMI1 is rapidly recruited to sites of DNA double strand breaks where it facilitates histone H2A ubiquitination and DN...

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Bibliographic Details
Main Authors: Nibedita Patel, Koteswara Rao Garikapati, Raj K. Pandita, Dharmendra Kumar Singh, Tej K. Pandita, Utpal Bhadra, Manika Pal Bhadra
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02800-2

Internet

https://doi.org/10.1038/s41598-017-02800-2

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