Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

Tcf4 Regulates Synaptic Plasticity, DNA Methylation, and Memory Function

Human haploinsufficiency of the transcription factor Tcf4 leads to a rare autism spectrum disorder called Pitt-Hopkins syndrome (PTHS), which is associated with severe language impairment and development delay. Here, we demonstrate that Tcf4 haploinsufficient mice have deficits in social interaction...

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Bibliographic Details
Main Authors: Andrew J. Kennedy, Elizabeth J. Rahn, Brynna S. Paulukaitis, Katherine E. Savell, Holly B. Kordasiewicz, Jing Wang, John W. Lewis, Jessica Posey, Sarah K. Strange, Mikael C. Guzman-Karlsson, Scott E. Phillips, Kyle Decker, S. Timothy Motley, Eric E. Swayze, David J. Ecker, Todd P. Michael, Jeremy J. Day, J. David Sweatt
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Subjects:
epigenetics
Pitt-Hopkins syndrome
transcription factor 4
E2-2
neuroepigenetics
DNA methylation
learning and memory
next-generation sequencing
HDAC inhibitor
schizophrenia
language
transcription
autism
social interactions
autism spectrum disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310361

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http://www.sciencedirect.com/science/article/pii/S2211124716310361

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