Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function

Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function

P-glycoprotein (P-gp) effluxes lots of chemotherapeutic agents and leads to multidrug resistance (MDR) in cancer treatments. The development of P-gp inhibitors from natural products provide a potential strategy for the beneficial clinical outcomes. This study aimed to evaluate the effects of the nat...

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Bibliographic Details
Main Authors: Hsiu-Ju Chen, Yun-Lung Chung, Chia-Ying Li, Ying-Tzu Chang, Charles C. N. Wang, Hsiang-Yen Lee, Hui-Yi Lin, Chin-Chuan Hung
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
taxifolin
quercetin
P-glycoprotein
multidrug resistance
kinetic mechanism
Online Access:https://www.mdpi.com/1420-3049/23/12/3055

Internet

https://www.mdpi.com/1420-3049/23/12/3055

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