Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy

Targeting NF-κB by the Cell-Permeable NEMO-Binding Domain Peptide Improves Albuminuria and Renal Lesions in an Experimental Model of Type 2 Diabetic Nephropathy

Diabetic nephropathy (DN) is a multifactorial disease characterized by hyperglycemia and close interaction of hemodynamic, metabolic and inflammatory factors. Nuclear factor-κB (NF-κB) is a principal matchmaker linking hyperglycemia and inflammation. The present work investigates the cell-permeable...

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Bibliographic Details
Main Authors: Lucas Opazo-Ríos, Anita Plaza, Yenniffer Sánchez Matus, Susana Bernal, Laura Lopez-Sanz, Luna Jimenez-Castilla, Daniel Carpio, Alejandra Droguett, Sergio Mezzano, Jesús Egido, Carmen Gomez-Guerrero
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic nephropathy
inflammation
albuminuria
NF-κB pathway
BTBR ob/ob mice
Online Access:https://www.mdpi.com/1422-0067/21/12/4225

Internet

https://www.mdpi.com/1422-0067/21/12/4225

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