Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine.

BACKGROUND:We developed a novel intranasal influenza vaccine approach that is based on the construction of replication-deficient vaccine viruses that lack the entire NS1 gene (DeltaNS1 virus). We previously showed that these viruses undergo abortive replication in the respiratory tract of animals. T...

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Bibliographic Details
Main Authors:	Julia Romanova, Brigitte M Krenn, Markus Wolschek, Boris Ferko, Ekaterina Romanovskaja-Romanko, Alexander Morokutti, Anna-Polina Shurygina, Sabine Nakowitsch, Tanja Ruthsatz, Bettina Kiefmann, Ulrich König, Michael Bergmann, Monika Sachet, Shobana Balasingam, Alexander Mann, John Oxford, Martin Slais, Oleg Kiselev, Thomas Muster, Andrej Egorov
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2009-06-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2694350?pdf=render

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http://europepmc.org/articles/PMC2694350?pdf=render

Preclinical evaluation of a replication-deficient intranasal DeltaNS1 H5N1 influenza vaccine.

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