Investigation of Pharmaceutical Importance of 2<i>H</i>-Pyran-2-One Analogues via Computational Approaches

Investigation of Pharmaceutical Importance of 2<i>H</i>-Pyran-2-One Analogues via Computational Approaches

Highly functionalized spirocyclic ketals were synthesized through asymmetric oxidative spirocyclization via carbanion-induced ring transformation of 2<i>H</i>-pyran-2-ones with 1,4-cyclohexandione monoethyleneketal under alkaline conditions. Further acidic-hydrolysis of obtained spirocyc...

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Bibliographic Details
Main Authors: Samata E. Shetgaonkar, Shiva Prasad Kollur, Renjith Raveendran Pillai, Karthick Thangavel, Sanja J. Armaković, Stevan Armaković, Chandan Shivamallu, Raghavendra G. Amachawadi, Asad Syed, Abdallah M. Elgorban, Ali H. Bahkali, Fateh V Singh
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Symmetry
Subjects:
tetralone
DFT calculations
MD simulations
MEP
bond dissociation
Online Access:https://www.mdpi.com/2073-8994/13/9/1619

Internet

https://www.mdpi.com/2073-8994/13/9/1619

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