Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

The present paper reports a thorough continuous powder blending process design of acetylsalicylic acid (ASA) and microcrystalline cellulose (MCC) based on the Process Analytical Technology (PAT) guideline. A NIR-based method was applied using multivariate data analysis to achieve in-line process mon...

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Bibliographic Details
Main Authors: Martin Gyürkés, Lajos Madarász, Ákos Köte, András Domokos, Dániel Mészáros, Áron Kristóf Beke, Brigitta Nagy, György Marosi, Hajnalka Pataki, Zsombor Kristóf Nagy, Attila Farkas
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
residence time distribution
continuous powder blending
operation block model
feeder selection
funnel plot
Online Access:https://www.mdpi.com/1999-4923/12/11/1119

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https://www.mdpi.com/1999-4923/12/11/1119

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