Uptake Study in Lysosome-Enriched Fraction: Critical Involvement of Lysosomal Trapping in Quinacrine Uptake but Not Fluorescence-Labeled Verapamil Transport at Blood-Retinal Barrier

Uptake Study in Lysosome-Enriched Fraction: Critical Involvement of Lysosomal Trapping in Quinacrine Uptake but Not Fluorescence-Labeled Verapamil Transport at Blood-Retinal Barrier

Lysosomal trapping at the blood–retinal barrier (BRB) was investigated through quinacrine and fluorescence-labeled verapamil (EFV) uptake. Quinacrine uptake by conditionally immortalized rat retinal capillary endothelial (TR-iBRB2) cells suggested saturable and non-saturable transport processes in t...

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Bibliographic Details
Main Authors: Yoshiyuki Kubo, Miki Yamada, Saki Konakawa, Shin-ichi Akanuma, Ken-ichi Hosoya
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
blood-retinal barrier
cationic drug
transport
lysosomal trapping
Online Access:https://www.mdpi.com/1999-4923/12/8/747

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https://www.mdpi.com/1999-4923/12/8/747

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