Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability

Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability

Ketamine exposure can lead to selective neuroapoptosis in the developing brain. p66ShcA, the cellular adapter protein expressed selectively in immature neurons, is a known pro-apoptotic molecule that triggers neuroapoptosis when activated. Sprague-Dawley rats at postnatal day 7 were subcutaneously i...

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Bibliographic Details
Main Authors: Dan Lyu, Ning Tang, Andrew W Womack, Yong-Jin He, Qing Lin
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
caspase-3; developmental neuroapoptosis; hippocampus; ketamine; morris water maze; n-methyl-d-aspartate acid receptors; p66shca; spatial learning
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=880;epage=886;aulast=Lyu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=880;epage=886;aulast=Lyu

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