Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability
Ketamine exposure can lead to selective neuroapoptosis in the developing brain. p66ShcA, the cellular adapter protein expressed selectively in immature neurons, is a known pro-apoptotic molecule that triggers neuroapoptosis when activated. Sprague-Dawley rats at postnatal day 7 were subcutaneously i...
Main Authors: | Dan Lyu, Ning Tang, Andrew W Womack, Yong-Jin He, Qing Lin |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2020-01-01
|
Series: | Neural Regeneration Research |
Subjects: | |
Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=5;spage=880;epage=886;aulast=Lyu |
Similar Items
-
Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration
by: Chainllie Young, et al.
Published: (2006-06-01) -
Hydrogen sulfide attenuates isoflurane-induced neuroapoptosis and cognitive impairment in the developing rat brain
by: Xueyuan Hu, et al.
Published: (2017-09-01) -
Intravenous sub-anesthetic ketamine for perioperative analgesia
by: Andrew W Gorlin, et al.
Published: (2016-01-01) -
Ketamine affects the integration of developmentally generated granule neurons in the adult stage
by: Zhanqiang Zhao, et al.
Published: (2019-12-01) -
Ketamine Administration Leads to Learning-Memory Dysfunction and Decreases Serum Brain-Derived Neurotrophic Factor in Rats
by: Miao Li, et al.
Published: (2020-09-01)