Necessity for retrospective evaluation of past-positive chemicals in in vitro chromosomal aberration tests using recommended cytotoxicity indices

Necessity for retrospective evaluation of past-positive chemicals in in vitro chromosomal aberration tests using recommended cytotoxicity indices

Abstract We have demonstrated that retrospective evaluation of existing data of in vitro chromosomal aberration test using the new cytotoxicity indices RICC (relative increase in cell count) or RPD (relative population doubling) reduces the false-positive rate. We have constructed an algorithm to pr...

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Bibliographic Details
Main Authors: Hiroshi Honda, Yurika Fujita, Toshio Kasamatsu, Anne Fuchs, Rolf Fautz, Osamu Morita
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Genes and Environment
Subjects:
Chromosomal aberration
Retrospective evaluation
Cytotoxicity index
In vitro genotoxicity test
Online Access:http://link.springer.com/article/10.1186/s41021-017-0091-y

Internet

http://link.springer.com/article/10.1186/s41021-017-0091-y

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