Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles

Synergistic Protective Activity of Tumor-Specific Epitopes Engineered in Bacterial Outer Membrane Vesicles

IntroductionBacterial outer membrane vesicles (OMVs) are naturally produced by all Gram-negative bacteria and, thanks to their plasticity and unique adjuvanticity, are emerging as an attractive vaccine platform. To test the applicability of OMVs in cancer immunotherapy, we decorated them with either...

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Bibliographic Details
Main Authors: Alberto Grandi, Michele Tomasi, Ilaria Zanella, Luisa Ganfini, Elena Caproni, Laura Fantappiè, Carmela Irene, Luca Frattini, Samine J. Isaac, Enrico König, Francesca Zerbini, Simona Tavarini, Chiara Sammicheli, Fabiola Giusti, Ilaria Ferlenghi, Matteo Parri, Guido Grandi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Oncology
Subjects:
bacterial outer membrane vesicles
cancer immunotherapy
EGRRvIII
cancer neoepitopes
BALB/c-CT26 cancer mouse model
precision medicine
Online Access:http://journal.frontiersin.org/article/10.3389/fonc.2017.00253/full

Internet

http://journal.frontiersin.org/article/10.3389/fonc.2017.00253/full

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