Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance. Recent data suggest that the survival of mTECs extends beyond the Aire+...

Full description

Bibliographic Details
Main Authors: Xiaoping eWang, Martti eLaan, Rudolf eBichele, Kai eKisand, Hamish S Scott, Pärt ePeterson
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-03-01
Series:Frontiers in Immunology
Subjects:
Central Tolerance
autoantigen
AIRE
Thymus
desmoglein
Hassall's corpuscle
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00019/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00019/full

Similar Items