Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP/p16 signals via m6A modulation

Total Panax notoginseng saponin inhibits vascular smooth muscle cell proliferation and migration and intimal hyperplasia by regulating WTAP/p16 signals via m6A modulation

Intimal hyperplasia, the key event of arterial restenosis, is a result of vascular smooth muscle cell (VSMC) proliferation and migration. Previous studies have demonstrated that total Panax notoginseng saponin (TPNS) represses intimal hyperplasia and inhibits the proliferation of VSMCs following bal...

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Bibliographic Details
Main Authors: Boqian Zhu, Yaoyao Gong, Le Shen, Jie Li, Jie Han, Bingzhan Song, Lianxia Hu, Qingjie Wang, Zhenxing Wang
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
TPNS
m6A
WTAP
p16
VSMCs
Rat carotid balloon injury
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220301256

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http://www.sciencedirect.com/science/article/pii/S0753332220301256

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