Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles.

Machine learning approaches offer the potential to systematically identify transcriptional regulatory interactions from a compendium of microarray expression profiles. However, experimental validation of the performance of these methods at the genome scale has remained elusive. Here we assess the gl...

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Bibliographic Details
Main Authors: Jeremiah J Faith, Boris Hayete, Joshua T Thaden, Ilaria Mogno, Jamey Wierzbowski, Guillaume Cottarel, Simon Kasif, James J Collins, Timothy S Gardner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0050008