CXCR5+CD8+ T Cells Shape Antibody Responses In Vivo Following Protein Immunisation and Peripheral Viral Infection

CXCR5+CD8+ T Cells Shape Antibody Responses In Vivo Following Protein Immunisation and Peripheral Viral Infection

Crosstalk between T and B cells is crucial for generating high-affinity, class-switched antibody responses. The roles of CD4+ T cells in this process have been well-characterised. In contrast, regulation of antibody responses by CD8+ T cells is significantly less defined. CD8+ T cells are principall...

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Bibliographic Details
Main Authors: Timona S. Tyllis, Kevin A. Fenix, Todd S. Norton, Ervin E. Kara, Duncan R. McKenzie, Shannon C. David, Mohammed Alsharifi, Di Yu, Shaun R. McColl, Iain Comerford
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
CXCR5+CD8+ T cells
class switching
immunization
infection
antibody response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.626199/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.626199/full

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