Systems-wide RNAi analysis of <it>CASP8AP2</it>/<it>FLASH </it>shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

Systems-wide RNAi analysis of <it>CASP8AP2</it>/<it>FLASH </it>shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells

<p>Abstract</p> <p>Background</p> <p>Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC cells can be used to further und...

Full description

Bibliographic Details
Main Authors: Hummon Amanda B, Pitt Jason J, Camps Jordi, Emons Georg, Skube Susan B, Huppi Konrad, Jones Tamara L, Beissbarth Tim, Kramer Frank, Grade Marian, Difilippantonio Michael J, Ried Thomas, Caplen Natasha J
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Molecular Cancer
Subjects:
<it>CASP8AP2</it>
<it>FLASH</it>
RNAi screening
RNAi analysis
siRNA
replication-dependent histone transcripts
Online Access:http://www.molecular-cancer.com/content/11/1/1

Internet

http://www.molecular-cancer.com/content/11/1/1

Similar Items