Effects of the Q80K Polymorphism on the Physicochemical Properties of Hepatitis C Virus Subtype 1a NS3 Protease

Effects of the Q80K Polymorphism on the Physicochemical Properties of Hepatitis C Virus Subtype 1a NS3 Protease

Hepatitis C virus genotype 1a (HCV-1a) comprises clades I and II. The Q80K polymorphism is found predominantly in clade I but rarely in clade II. Here, we investigated whether natural polymorphisms in HCV-1a clade II entailed structural protein changes when occurrence of the Q80K variant was simulat...

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Bibliographic Details
Main Authors: Allan Peres-da-Silva, Deborah Antunes, André Luiz Quintanilha Torres, Ernesto Raul Caffarena, Elisabeth Lampe
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Viruses
Subjects:
hepatitis C virus
Q80K variant
polymorphisms
NS3 protease
simulation
molecular dynamics
network analysis
Online Access:https://www.mdpi.com/1999-4915/11/8/691

Internet

https://www.mdpi.com/1999-4915/11/8/691

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