GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands.

GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands.

In response to pathogen recognition by Toll-like receptors (TLRs) on their cell surface, macrophages release lipid mediators and cytokines that are widely distributed throughout the body and play essential roles in host responses. Granulocyte macrophage colony-stimulating factor (GM-CSF) is importan...

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Bibliographic Details
Main Authors: Carlos Arterio Sorgi, Stephanie Rose, Nathalie Court, Daniela Carlos, Francisco Wanderley Garcia Paula-Silva, Patricia Aparecida Assis, Fabiani Gai Frantz, Bernhard Ryffel, Valerie Quesniaux, Lúcia Helena Faccioli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3396658?pdf=render

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http://europepmc.org/articles/PMC3396658?pdf=render

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