Extracellular Superoxide Dismutase, the Endothelial Basement Membrane, and the WNT Pathway: New Players in Vascular Normalization and Tumor Infiltration by T-Cells

Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of cancer and the response to immunotherapy. In primary cancers, however, TILs are commonly absent, suggesting T-cell entry into the tumor microenvironment (TME) to be selectively restricted. Blood and lymph vesse...

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Bibliographic Details
Main Authors: Diego Martínez-Rey, Lorena Carmona-Rodríguez, María Jesús Fernández-Aceñero, Emilia Mira, Santos Mañes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.579552/full