AATF/Che-1—An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis

AATF/Che-1—An RNA Binding Protein at the Nexus of DNA Damage Response and Ribosome Biogenesis

The DNA damage response (DDR) is a complex signaling network that is activated upon genotoxic stress. It determines cellular fate by either activating cell cycle arrest or initiating apoptosis and thereby ensures genomic stability. The Apoptosis Antagonizing Transcription Factor (AATF/Che-1), an RNA...

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Bibliographic Details
Main Authors: Rainer W. J. Kaiser, Johanna Erber, Katja Höpker, Francesca Fabretti, Roman-Ulrich Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
AATF/Che-1
DNA damage response
p53
ribosome biogenesis
rRNA processing
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00919/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00919/full

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