Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

Individual microtubules (MTs) in the axon consist of a stable domain that is highly acetylated and a labile domain that is not. Traditional MT-severing proteins preferentially cut the MT in the stable domain. In Drosophila, fidgetin behaves in this fashion, with targeted knockdown resulting in neuro...

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Bibliographic Details
Main Authors: Lanfranco Leo, Wenqian Yu, Mitchell D’Rozario, Edward A. Waddell, Daniel R. Marenda, Michelle A. Baird, Michael W. Davidson, Bin Zhou, Bingro Wu, Lisa Baker, David J. Sharp, Peter W. Baas
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715008888

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http://www.sciencedirect.com/science/article/pii/S2211124715008888

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