Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity

Controlled Fab installation onto polymeric micelle nanoparticles for tuned bioactivity

Antibodies and antigen-binding fragments (Fabs) can be used to modify the surface of nanoparticles for enhanced target binding. In our previous work, site-specific conjugation of Fabs to polymeric micelles using conventional methods was limited to approximately 30% efficiency, possibly due to steric...

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Bibliographic Details
Main Authors: Shaoyi Chen, Stelios Florinas, Abigail Teitgen, Ze-Qi Xu, Changshou Gao, Herren Wu, Kazunori Kataoka, Horacio Cabral, R. James Christie
Format: Article
Language:English
Published: Taylor & Francis Group 2017-12-01
Series:Science and Technology of Advanced Materials
Subjects:
Polymeric micelle
Fab modification
conjugation efficiency
ligand density
bioactivity
Online Access:http://dx.doi.org/10.1080/14686996.2017.1370361

Internet

http://dx.doi.org/10.1080/14686996.2017.1370361

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