TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer

TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer

Cancer cells adopt glycolysis to facilitate the generation of biosynthetic substrates demanded by cell proliferation and growth, and to adapt to stress conditions such as excessive reactive oxygen species (ROS) accumulation. TIGAR (TP53-induced glycolysis and apoptosis regulator) is a fructose-2,6-b...

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Bibliographic Details
Main Authors: Zhenhua Liu, Yue Wu, Yingqiu Zhang, Menglang Yuan, Xuelu Li, Jiyue Gao, Shanni Zhang, Chengjuan Xing, Huamin Qin, Hongbo Zhao, Zuowei Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
apoptosis
cell cycle checkpoints
glycolysis
heterografts
stomach neoplasms
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01258/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01258/full

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