Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism

Antimetabolites, in particular nucleobase and nucleoside analogues, are cytotoxic drugs that, starting from the small field of paediatric oncology, in combination with other chemotherapeutics, have revolutionised clinical oncology and transformed cancer into a curable disease. However, even though c...

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Bibliographic Details
Main Authors: Nikolaos Tsesmetzis, Cynthia B. J. Paulin, Sean G. Rudd, Nikolas Herold
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Cancers
Subjects:
chemoresistance
sensitisation
novel therapy
combination therapy
antimetabolites
nucleoside analogues
nucleobase analogues
cytarabine
gemcitabine
clofarabine
fludarabine
nelarabine
cladribine
5-fluorouracil
capecitabine
SAMHD1
ribonucleotide reductase
precision medicine
Online Access:http://www.mdpi.com/2072-6694/10/7/240

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http://www.mdpi.com/2072-6694/10/7/240

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