Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT

Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT

BackgroundNon-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated by pro-inflammatory Th1 and Th17 T-cell subsets. S...

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Bibliographic Details
Main Authors: Rose M. Gilbert, Xiaozhe Zhang, Robert D. Sampson, Michael R. Ehrenstein, Dao X. Nguyen, Mahid Chaudhry, Charles Mein, Nadiya Mahmud, Grazyna Galatowicz, Oren Tomkins-Netzer, Virginia L. Calder, Sue Lightman
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
uveitis
T-regulatory cells
TIGIT
T-bet
ocular inflammation
remission
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00907/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00907/full

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