Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanisti...
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2018-01-01
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Series: | NeuroImage: Clinical |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217302632 |
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doaj-b4308c9929ef4302b37f33f5c7d08710 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lora Minkova Sarah Gregory Rachael I. Scahill Ahmed Abdulkadir Christoph P. Kaller Jessica Peter Jeffrey D. Long Julie C. Stout Ralf Reilmann Raymund A. Roos Alexandra Durr Blair R. Leavitt Sarah J. Tabrizi Stefan Klöppel |
spellingShingle |
Lora Minkova Sarah Gregory Rachael I. Scahill Ahmed Abdulkadir Christoph P. Kaller Jessica Peter Jeffrey D. Long Julie C. Stout Ralf Reilmann Raymund A. Roos Alexandra Durr Blair R. Leavitt Sarah J. Tabrizi Stefan Klöppel Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease NeuroImage: Clinical |
author_facet |
Lora Minkova Sarah Gregory Rachael I. Scahill Ahmed Abdulkadir Christoph P. Kaller Jessica Peter Jeffrey D. Long Julie C. Stout Ralf Reilmann Raymund A. Roos Alexandra Durr Blair R. Leavitt Sarah J. Tabrizi Stefan Klöppel |
author_sort |
Lora Minkova |
title |
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease |
title_short |
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease |
title_full |
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease |
title_fullStr |
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease |
title_full_unstemmed |
Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's disease |
title_sort |
cross-sectional and longitudinal voxel-based grey matter asymmetries in huntington's disease |
publisher |
Elsevier |
series |
NeuroImage: Clinical |
issn |
2213-1582 |
publishDate |
2018-01-01 |
description |
Huntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies. Keywords: Huntington's disease, Asymmetries, Grey matter volume, MRI, VBM |
url |
http://www.sciencedirect.com/science/article/pii/S2213158217302632 |
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doaj-b4308c9929ef4302b37f33f5c7d087102020-11-25T02:32:41ZengElsevierNeuroImage: Clinical2213-15822018-01-0117312324Cross-sectional and longitudinal voxel-based grey matter asymmetries in Huntington's diseaseLora Minkova0Sarah Gregory1Rachael I. Scahill2Ahmed Abdulkadir3Christoph P. Kaller4Jessica Peter5Jeffrey D. Long6Julie C. Stout7Ralf Reilmann8Raymund A. Roos9Alexandra Durr10Blair R. Leavitt11Sarah J. Tabrizi12Stefan Klöppel13Department of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Freiburg, Germany; Freiburg Brain Imaging Center, Medical Center – University of Freiburg, Germany; Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany; Corresponding author at: Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Freiburg Brain Imaging, Breisacher Str. 64, 79106 Freiburg, Germany.Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UKDepartment of Neurodegenerative Disease, Institute of Neurology, University College London, London, UKDepartment of Computer Science, University of Freiburg, Freiburg, Germany; University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandFreiburg Brain Imaging Center, Medical Center – University of Freiburg, Germany; Department of Neurology, Medical Center – University of Freiburg, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Freiburg, GermanyDepartment of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Freiburg, Germany; University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandDepartment of Psychiatry, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA; Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City, IA, USASchool of Psychology and Psychiatry, Monash University, Victoria, AustraliaGeorge-Huntington-Institute, Münster, Germany; Department of Radiology, University of Münster, Münster, Germany; Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanyDepartment of Neurology, Leiden University Medical Centre, Leiden, NetherlandsAPHP Department of Genetics, ICM (Brain and Spine Institute) Pitié-Salpêtrière University Hospital Paris, FranceCentre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, CanadaDepartment of Neurodegenerative Disease, Institute of Neurology, University College London, London, UKDepartment of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Freiburg, Germany; University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Bern, SwitzerlandHuntington's disease (HD) is a progressive neurodegenerative disorder that can be genetically confirmed with certainty decades before clinical onset. This allows the investigation of functional and structural changes in HD many years prior to disease onset, which may reveal important mechanistic insights into brain function, structure and organization in general. While regional atrophy is present at early stages of HD, it is still unclear if both hemispheres are equally affected by neurodegeneration and how the extent of asymmetry affects domain-specific functional decline. Here, we used whole-brain voxel-based analysis to investigate cross-sectional and longitudinal hemispheric asymmetries in grey matter (GM) volume in 56 manifest HD (mHD), 83 pre-manifest HD (preHD), and 80 healthy controls (HC). Furthermore, a regression analysis was used to assess the relationship between neuroanatomical asymmetries and decline in motor and cognitive measures across the disease spectrum. The cross-sectional analysis showed striatal leftward-biased GM atrophy in mHD, but not in preHD, relative to HC. Longitudinally, no net 36-month change in GM asymmetries was found in any of the groups. In the regression analysis, HD-related decline in quantitative-motor (Q-Motor) performance was linked to lower GM volume in the left superior parietal cortex. These findings suggest a stronger disease effect targeting the left hemisphere, especially in those with declining motor performance. This effect did not change over a period of three years and may indicate a compensatory role of the right hemisphere in line with recent functional imaging studies. Keywords: Huntington's disease, Asymmetries, Grey matter volume, MRI, VBMhttp://www.sciencedirect.com/science/article/pii/S2213158217302632 |