Titrating Growth Hormone Dose to High-Normal IGF-1 Levels Has Beneficial Effects on Body Fat Distribution and Microcirculatory Function Despite Causing Insulin Resistance

Titrating Growth Hormone Dose to High-Normal IGF-1 Levels Has Beneficial Effects on Body Fat Distribution and Microcirculatory Function Despite Causing Insulin Resistance

To clarify the mechanism underlying the described U-shaped relation of both low and high levels of IGF-1 with cardiovascular disease this study explores the effect of decreasing and increasing growth hormone dose in GH deficient adults on (micro)vascular function, body composition and insulin resist...

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Bibliographic Details
Main Authors: Christa C. van Bunderen, Rick I. Meijer, Paul Lips, Mark H. Kramer, Erik H. Serné, Madeleine L. Drent
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
growth hormone
insulin-like growth factor-1
growth hormone deficiency in adults
insulin resistance
vasomotion
vascular endothelium
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.619173/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.619173/full

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