Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA

Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA

How BRCA1 germline mutations predispose to cancer remains poorly understood. Induced pluripotent stem cells (iPSCs) represent an emerging model to investigate the molecular mechanisms underlying malignant transformation in primary cells from individuals who are carriers of deleterious mutations in t...

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Bibliographic Details
Main Authors: Teresa P. Silva, Carolina A. Pereira, Ana Rita Oliveira, Ana Cláudia Raposo, Maria Arez, Joaquim M.S. Cabral, Inês Milagre, Maria Carmo-Fonseca, Simão T. da Rocha
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S187350612100088X

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http://www.sciencedirect.com/science/article/pii/S187350612100088X

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